The Sanctuary of Loyola or ‘’’Sanctuary of Loiola’’’ Shrine and Basilica of Loyola (Spanish: Santuario de Loyola; Basque: Loiolako Santutegia) consists of a series of edifices built in Churrigueresque Baroque style around the birthplace of St. Ignatius of Loyola, founder of the Society of Jesus.

The sanctuary stands along the river Urola at the neighbourhood of Loyola (Loiola, a place-name meaning 'foundry made in clad', or possibly 'hut made in clad') in the municipality of Azpeitia, Basque Country, Spain.

Ignatius of Loyola, whose real name was Iñigo López de Loyola, was the son of the Lord of Loyola, Beltrán Ibáñez de Oñaz and Marina Sánchez de Licona, member of an important Biscayan family. He was born in 1491 in his family house in Loyola.

After he died his birthplace became a place of veneration. In the seventeenth century the house where he was born was given to the Society of Jesus. The Order built there, near the birthplace of its founder, the Sanctuary of Loyola.